Development

A model finds a programmable DNA-targeting system that predates CRISPR

development2026-04-29

Claim

The Doudna Lab used a genomic foundation model to discover a programmable RNA-guided DNA-targeting system hidden inside bacteriophages that predates CRISPR and operates on entirely different logic.

Reporting date: 2026-04-29 (not necessarily the event date)

Sources

Attribution and reporting linked by this record; links do not imply independent verification.

Welcome to April 29, 2026 (theinnermostloop.substack.com)

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Reported in

Welcome to April 29, 2026

Actor

Doudna Lab

Evidence for

Supersedes

Integrated organ networks are grown inside animal wombs

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A model finds a programmable DNA-targeting system that predates CRISPR
Innermost Loop KB — secondary record
Reporting date: 2026-04-29
KB permalink: https://nicholsn.github.io/innermost-loop-kb/developments/2026-04-29-a-targeting-system-older-than-crispr
Claim: The Doudna Lab used a genomic foundation model to discover a programmable RNA-guided DNA-targeting system hidden inside bacteriophages that predates CRISPR and operates on entirely different logic.
Attributed sources:
- Welcome to April 29, 2026 — https://theinnermostloop.substack.com/p/welcome-to-april-29-2026
This citation does not imply independent verification of linked-source claims.

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