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A hybrid model plus robotic experiments yields hundred-fold enzyme gains

development2026-08-04

Claim

Tianjin's REAP pairs a hybrid-loss model with robotic experiments for a 57-fold activity gain in cytochrome P450 BM3 in five cycles and 104-fold in Sortase A.

Reported metric: 57x and 104x

Reporting date: 2026-08-04 (not necessarily the event date)

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Welcome to August 4, 2026 (theinnermostloop.substack.com)

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A hybrid model plus robotic experiments yields hundred-fold enzyme gains
Innermost Loop KB — secondary record
Reporting date: 2026-08-04
KB permalink: https://nicholsn.github.io/innermost-loop-kb/developments/2026-08-04-a-hundred-fold-activity-gain-in-five-cycles
Claim: Tianjin's REAP pairs a hybrid-loss model with robotic experiments for a 57-fold activity gain in cytochrome P450 BM3 in five cycles and 104-fold in Sortase A.
Attributed sources:
- Welcome to August 4, 2026 — https://theinnermostloop.substack.com/p/welcome-to-august-4-2026
This citation does not imply independent verification of linked-source claims.

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